Fisetin
528-48-3
Fisetin
Fisetin is a naturally occurring flavonol with multiple biological activities, primarily used in pharmacological research for content determination, activity identification, and as a precursor for synthesizing anti-inflammatory and anticonvulsant drugs. Additionally, it has shown potential in research on improving memory.
Overview
Fisetin is a pharmaceutical raw material and natural active substance, derived from plants of the Anacardiaceae family such as Rhus succedanea L. and Cotinus coggygria. It appears as yellow needle-shaped crystals. A team of researchers from Japan and the United States found through animal experiments that fisetin present in vegetables and fruits may help improve memory.
EINECS: 208-434-4
Product Categories: Biochemistry;Flavonoids;Flavanols;Building block;natural product;Inhibitors;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;research chem
Characteristics
Appearance, Form & Color: Solid, Pale Yellow to Very Dark Yellow
Melting Point: >330 °C(lit.)
Boiling Point: 348.61°C (rough estimate)
Density: 1.2981 (rough estimate)
Refractive Index: 1.4413 (estimate)
Storage Temperature: Sealed in dry, Store in freezer, under -20°C
Solubility: DMSO (Slightly), Methanol (Slightly)
pKa: 6.83±0.40 (Predicted)
LogP: 1.970 (est)
Stability: Hygroscopic
Applications
Fisetin is primarily used as a research chemical and a precursor in drug synthesis, with specific applications in the following areas:
1. Laboratory Research and Analysis:
Content Determination and Identification: This product is directly used for content determination, identification, and pharmacological experiments in scientific research and analysis.
2. Drug Synthesis:
Active Precursor: As a naturally occurring therapeutically active flavonol, it is used for the synthesis of compounds with pharmaceutical activity, particularly anti-inflammatory, anticonvulsant, and antiproliferative drugs.
3. Pharmacological Efficacy Research (Based on animal and in vitro studies):
Prostaglandin Inhibition: It inhibits prostaglandin production in methylcholanthrene-transformed 3T3 mouse fibroblasts.
Enzyme Inhibition: It inhibits aldose reductase in rat eye lenses.
Neuroprotection and Cognitive Improvement: Animal experiments suggest it may help improve memory.
| File Name | Download |
|---|---|
| COA Fisetin 85% 528-48-3.pdf |
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